ObjectiveTo evaluate the characteristics and  risk factors for healthcareassociated infections(HAI)  in patients with liver cirrhosis, so as to make effective strategies to prevent and control the occurrence of HAI.  MethodsClinical data of  hospitalized patients with liver cirrhosis in a hospital from January to December 2013 were collected,occurrence of HAI, distribution of pathogens，and risk factors were analyzed.ResultsOf 507 patients with liver cirrhosis,48 (9.47%) had HAI，the main infection site was intraabdominal （31.25%）；48 specimens(100.00%) were sent for bacterial culture; a total of 43 isolates of pathogens were detected，isolation rate of gramnegative bacteria, grampositive bacteria,and fungi was 58.14% (n=25）, 23.26%（n=10）, and 18.60% (n=8）respectively；the incidence of HAI were different among cirrhosis patients with different age,  length of hospitalization, white blood count, albumin levels,the grade of liver function, invasive procedure, complications, prophylactic use of antimicrobial agents respectively (all P<0.05%).  ConclusionThe incidence of HAI in patients with liver cirrhosis is high, risk factors for HAI are multiple, corresponding intervention measures  should be formulated according to the risk factors, so as to reduce the occurrence of HAI.