Abstract:ObjectiveTo investigate the effect of antimicrobialimpregnated incise drape on preventing surgical site infection(SSI) following neurosurgical operation.MethodsPatients undergoing neurosurgical operation from January to December 2012 were divided into two groups: antimicrobialimpregnated incise drape group(group A) and general incise drape group(group B). The occurrence of SSI and risk factors for SSI were analyzed.ResultsPercentage of drape lifting at the wound edge in group A was lower than group B(38.3%［98/256］ vs 96.88% ［248/256］, χ2=200.57，P＜0.01）. Among 512 patients, SSI rate was 3.32%(n=17), SSI rate in group A was lower than group B(1.56%［4/256］ vs 5.08%［13/256］, χ2= 7.93，P＜0.05 ). Multivariate analysis revealed that body mass index ≥24, perioperative hypothermia, smoking, perioperative length of hospital stay ≥5 days, and lack of drape use were independent risk factors for SSI following neurosurgical operation.ConclusionWhether antimicrobialimpregnated incise drape is used in neurosurgical operation is one of the independent risk factors for SSI following neurosurgical operation, it can effectively reduce the drape lifting rate and incidence of SSI, and is recommended to be used in neurosurgical operation.