ObjectiveTo evaluate the risk factors for healthcareassociated infection (HAI) in patients in department of cardiology.MethodsClinical data of inpatients were performed retrospective casecontrol analysis, patients with HAI  were as case group, while without HAI were as control group, factors for HAI between two groups were compared.Results117 cases of HAI occurred among  2 308 patients, infection rate was 5.07%. The main infection site was respiratory tract (n=71,60.68%); a total of 90 pathogenic isolates were isolated, gramnegative bacteria, grampositive bacteria,  and fungi accounted for  72.22%(n=65), 22.22%(n=20), and 5.56%(n=5) respectively. Univariate analysis revealed that 7 variables were risk factors for HAI,  multivariate nonconditional logistic regression analysis revealed that independent risk factors for HAI were age, cardiac function classification, serum albumin level,and invasive operation.ConclusionHAI rate is higher among cardiology inpatients, which is related to many factors. Attention should be paid to the elderly, long term hospitalization, heart failure correcting, treatment for complications,reducing of invasive procedure, and strict sterile manipulation.