ObjectiveTo study the early diagnostic value of procalcitonin（PCT）, highsensitivity Creactive protein（hsCRP） and interleukin6（IL6） in catheterrelated bloodstream infection (CRBSI)  in patients in intensive care unit(ICU).Methods78 ICU patients with suspected CRBSI between April 2013 and April 2015 were selected, blood specimens of patients on the first day of admission and being suspected CRBSI were taken, blood and venous catheter tips were performed culture, patients were divided into CRBSI group and nonCRBSI group according to culture results of blood and venous catheter tips, diagnostic values of PCT, hsCRP, and IL6 were compared.  Results28  patients were diagnosed CRBSI. On the day of  being suspected with CRBSI, levels of PCT, hsCRP,  IL6, and white blood cell(WBC)  in CRBSI group were significantly higher than nonCRBSI group respectively(［3.35±1.52］μg/L vs ［1.22±0.44］μg/L; ［32.90±11.10］mg/L vs ［23.50±6.00］mg/L; ［423.20±171.70］ng/L vs ［257.90±81.40］ng/L; ［12.70±2.70］×109/L vs ［11.20±1.90］×109/L］，P＜0.05 ). The receiver operating characteristic curve(ROC)  analysis showed that area under the curve (AUC)  and  95% CI of  PCT, hsCRP,  IL6, and WBC were 0.92（0.85，0.99）,0.75（0.62, 0.88）,0.80（0.67, 0.92）, and 0.64（0.50, 0.72）respectively；sensitivity were 0.82,0.64,0.71, and 0.46 respectively；specificity were 0.92,0.94, 0.92,and 0.88 respectively.  ConclusionPCT and IL6 have high effectiveness for early diagnosis of CRBSI in ICU patients, and have certain predictive value for early diagnosis of CRBSI.