ObjectiveTo explore clinical therapeutic effect of cattle encephalon glycoside and ignotin (EGI) on adjunctive therapy of severe handfootandmouth disease (HFMD). Methods94 children with severe HFMD in a hospital were selected and divided into two groups according to the parity of patients’  admission numbers， 46 children in control group were given conventional therapy; 48 children in trial group were given EGI adjunctive therapy based on conventional therapy, therapeutic effect of two groups was compared. ResultsThe total therapeutic effective rate in trial group was significantly higher than that of control group (95.83% vs 76.09%， χ2=16.81,P＜0.001）. Neurological function score was not significantly different between two groups before therapy(P＞0.05）; after therapy, neurological function score in trial group was significantly lower than control group (［4.07±0.13］ vs ［5.59±0.18］, χ2=18.19,P＜0.05）. The recovery time of temperature, heart rate, blood pressure, and breathing，as well as  length of stay in hospital in trial group were all significantly shorter than control group（P＜0.05）；incidence of complications in trial group was lower than control group (4.17%［n=2］ vs 21.74%［n=10］,χ2=10.08, P＜0.001）. The proportion of turning into critically ill cases in trial group was significantly lower than control group (2.08% ［n=1］vs 13.04%［n=6］, χ2=8.94, P＜0.001）.ConclusionEGI has remarkable efficacy in adjunctive therapy of severe HFMD, which can effectively improve clinical symptoms, and  is worthy to be  popularized and applied.