ObjectiveTo evaluate risk factors for multidrugresistant organisms(MDRO)  pulmonary infection in elderly patients in a hospital, and provide scientific basis for prevention and control of MDRO infection.Methods188 elderly patients who developed pulmonary infection between August 2010 and December 2012 were divided into MDR group (n=95) and nonMDR group (n=93) according to sputum bacterial culture results, clinical data of two groups of patients were analyzed.Results102 strains of  MDROs were isolated from patients with MDRO pulmonary infection, the top three were Acinetobacter baumannii (31.37%), Pseudomonas aeruginosa (25.49%), and methicillinresistant Staphylococcus aureus (15.69%). Univariate analysis showed that 7 risk factors for MDRO  pulmonary infection in elderly patients were  history of cerebrovascular disease or dementia, hypoproteinemia, dysphagia, bedridden, history of ICU hospitalization, recent application of 3,4generation cephalosporins, and invasive procedures. Multivariate logistic  regression analysis showed that hypoproteinemia (OR,6.02［95%CI,1.50-24.18］)，invasive procedures (OR,6.55 ［95%CI,1.69-25.44］), and bedridden (OR,6.03 ［95%CI,1.92-18.91］) were independent risk factors for MDRO  pulmonary infection in elderly patients.ConclusionMultiple factors contribute to MDRO pulmonary infection in elderly patients, comprehensive prevention and control measures should be taken against the risk factors, so as to prevent and control MRDO pulmonary infection in elderly patients.