ObjectiveTo investigate the incidence and influencing factors for sharp injuries occurred in workers in central sterile supply departments (CSSDs).MethodsIn OctoberNovember 2012, a multicenter crosssectional survey was conducted, a total of 95 workers in CSSDs of 16 hospitals in Hunan Province were surveyed through questionnaires.ResultsA total of 89 workers (93.68%) in CSSDs sustained  sharp injuries, 46 (48.42%) of whom sustained 1-5 times of sharp injuries, 22(23.16%) sustained 6-10 times of sharp injuries, and 11 (11.58%) sustained for at least 10 times of sharp injuries. 81 workers (85.26%) sustained at least one time of sharp injuries one year before survey, 52(54.73%) of whom were injured  by contaminated needles or other sharps. Logistic regression analysis revealed that higher educational background was protective factor for sharp injuries（OR 90%CI: 0.05-0.87）; while poor sleep quality（OR 90%CI: 1.03-17.94）,  frequent touching  sharps（OR 90%CI: 1.11-12.15）, and irrational placing of objects by the other medical stuff (surgeons and nurses in operating rooms) （OR 90%CI: 1.23-16.98) were the risk factors for sharp injuries.ConclusionThe incidence of sharp injuries among workers in CSSDs is high, which is related to personal factors and environmental factors. It is suggested to strengthen staff  training to enhance their awareness of precaution.