ObjectiveTo investigate the incidence and risk factors for surgical site infection (SSI) in clean wound orthopedics surgery.MethodsSSI among patients receiving clean wound orthopedic surgery from April 1 to September 30 in 2014 were monitored, risk factors for SSI were analyzed.ResultsA total of 665 patients were monitored, 14 cases(2.11%)  of SSI occurred. Univariate analysis  showed that types of skin, skin preparation modes, and ASA score were risk factors for SSI in clean wound orthopedic surgery  (all P＜0.05）. Multivariate logistic analysis revealed that conventional skin preparation,ASA score ≥ grade Ⅱ, and duration of operation ≥90 minutes were independent risk factors for SSI in patients receiving clean wound orthopedic surgery (OR［95%CI］, 3.96［1.07-14.70］,6.45［1.97-21.11］, and 4.08［1.35-12.30］ respectively）.ConclusionThe improved method of skin preparation, grade I ASA score, and shortening duration of operation can reduce the incidence of SSI in clean wound orthopedic surgery, on the basis of improving the autoimmunization of patients, strengthening  prevention and control of healthcareassociated infection can reduce the incidence of SSI in clean wound orthopedic surgery.