ObjectiveTo evaluate the correlation between occupational exposure and work intensity of health care workers(HCWs) in an infectious diseases hospital for 5 consecutive years, and provide reference for occupational precaution.MethodsOccupational exposures cases reported between January 2010 and December 2014 were analyzed retrospectively, occupation types, exposure routes, and exposure sources were analyzed.ResultsA total of 228 cases of occupational exposure were reported, nurses and doctors were the major exposure population(75.44% and 19.30% respectively); occupational exposure mainly occurred during the infusion process(52.19%); hepatitis B was the main exposure source (71.05%),followed by human immunodeficiency virus (10.09%).The Pearson correlation coefficient between the occupational exposure rate of doctors and the ratio of doctors to patients was -0.849 (P＜0.05), and for nurses, the correlation coefficient was -0.823 (P＜0.05).ConclusionNurses are high risk population of occupational exposures, occupational exposure is most likely to occur during transfusion process, occupational exposure of doctors and nurses has a strong correlation with the work intensity.