ObjectiveTo explore the effect of quality control circle (QCC) activities on decreasing postoperative intracranial infection in patients with intracranial tumor.MethodsQCC activity group was set up and the activity theme was established, postoperative intracranial infections in patients with intracranial tumor in a hospital from May 2011 to June 2012 were analyzed retrospectively, causes of postoperative intracranial infection were analyzed, goals were set, feasibility was analyzed, effective rectification measures were made, and were compared with postoperative intracranial infection in patients after implemented QCC from January to December 2013.ResultsPostoperative intracranial infection rate in patients with intracranial tumor decreased from 11.01%（12/109） before implementing QCC activities to 3.64% （4/110）after implementing QCC activities（χ2=4.395，P=0.036）; antimicrobial usage rate elevated from 15.63%（5/32） to 36.36%（16/44）（χ2=3.985，P=0.046）when operation time ＞4 hours; qualification rate of surgical hand disinfection elevated from 50.00% （50/100）to 75.00%（75/100）（χ2=11.163，P=0.001）.ConclusionQCC activity can not only reduce the incidence of postoperative intracranial infection in patients with intracranial tumor, but also make participants master the skills of quality management.