ObjectiveTo investigate antimicrobial resistance and ceftriaxone resistance mechanisms in clinically isolated  nontyphoidal Salmonella(NTS), and provide evidence for the prevention and control of NTS infection and rational  use of antimicrobial agents.Methods108 NTS isolates were isolated from stool specimens of outpatients with acute diarrhea in the Second Hospital of Tianjin Medical University and Tianjin Medical University General Hospital from May to October of 2014, NTS were performed antimicrobial susceptibility testing; nonceftriaxonesusceptible isolates were typed by  serological, multilocus sequence (MLST),  and pulsedfield gel electrophoresis (PFGE) methods, extendedspectrum βlactamase (ESBL) detection and AmpC genes were detection.ResultsAmong 108 NTS isolates, monodrug resistance rate to 11 antimicrobial agents was 49.07%（n=53）, multidrug resistance rate was17.59%. Susceptibility rates to nalidixic acid, levofloxacin, ciprofloxacin, ceftriaxone, and ertapenem were 61.11%,66.67%,68.52%,97.22%, and 100.00% respectively.  Three nonceftriaxonesusceptible NTS isolates were detected,   2 were ST11 Salmonella enterica serotype (Sa8709,Sa8771),1 was ST34 Salmonella typhimurium serotype(Sa8763). Cluster analysis of PFGE revealed that Sa8709 was highly similar to Sa8771 strains（91.70%），but the similarity to  Sa8763 was low(55.80%); Sa8709 strain carried CTXM gene, Sa8771 strain carried CTXM and TEM genes, Sa8763 strain carried OXA gene. ConclusionClinically isolated NTS in this area are low resistant to fluoroquinolones, multidrug resistant strains  carrying ESBLs  have emerged.