ObjectiveTo understand drug resistance in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV /AIDS) after antiretroviral therapy(ART).MethodsArticles about drug resistance in HIV /AIDS patients after ART were retrieved from Wangfang data, China National Knowledge Infrastructure(CNKI)，and PubMed. Meta analysis were performed.Results15 articles （1 English and 14 Chinese）were extracted, quality score of 3,4,and 8 articles was 6,7, and 8 respectively.  Heterogeneity of the included studies showed the difference was significant (Q=45.98,P<0.001), there was heterogeneity, randomeffects models was conducted for Meta analysis,which revealed that the overall drug resistance rate in HIV/ AIDS patients in China was 4% (4%-5%); Begg’s test showed that P=0.012, there was publication bias. After articles were excluded through sensitivity analysis, the combined effect was still 4%(4%-5%).ConclusionThe overall drug resistance rate  in Chinese HIV/ AIDS patients  after ART  is not high.