ObjectiveTo evaluate whether there is a correlation among plasma levels of procalcitonin (PCT), Nterminal probrain natriuretic peptide (NTproBNP) and cardiac troponin T (cTnT) in patients with sepsis, as well as significance to prognosis of patients. Methods48 patients with sepsis  who were admitted to the intensive care unit of a hospital between September 2014 and March 2015 were chosen for study, patients were divided into severe and mild sepsis groups according to the disease condition, plasma levels of PCT,  NTproBNP, and cTnT  were detected, mortality of  patients were analyzed statistically,  relation between plasma levels of PCT,  NTproBNP, cTnT and patients’ death  were compared. ResultsThe plasma levels of PCT, NTproBNP and cTnT in severe sepsis group were significantly higher than those in mild sepsis group (all P＜0.05); mortality of mild sepsis group was significantly lower than that of severe sepsis group  (10.53%  vs  41.38%,  P＜0.05);  Levels of PCT, NTproBNP and cTnT levels in died patients were all higher than surviving patients ( all P<0.05); levels of  PCT and NTproBNP,  NTproBNP and cTnT were positively correlated respectively (rs= 0.337, P＜0.05; rs＝0.456，P=0.001, respectively ), while PCT was not significantly correlated with cTnT. Plasma levels of PCT, NTproBNP, and cTnT were all correlated with the prognosis of patients (P＜0.05), and is helpful for judging the prognosis of patients, combination of three indexes had  better prognostic value for the prognosis.ConclusionCombination detection of plasmid levels of PCT, NPproBNP, and cTnT can assess the severity of infection in patients with sepsis, and preliminarily judge the prognosis of patients with sepsis.