ObjectiveTo monitor the incidence of catheterassociated infection (CAI) in patients in general intensive care unit (ICU), and provide basis for taking proper prevention and control measures.MethodsTargeted monitoring method was conducted, incidence of  healthcareassociated infection (HAI)  among patients receiving urinary catheterization, intravascular catheterization, and tracheal intubation in the general ICU of a tertiary hospital between January 2012 and December  2013 were surveyed.ResultsA total of 299 ICU patients with catheterization were investigated,  the overall hospitalization days were 2 700 days, 41 patients developed 48 episodes of HAI, incidence of  HAI was  13.71%,  case incidence was 16.05%, incidence of  HAI per 1 000 catheter days was 15.19‰,  37 patients developed 44 episodes of CAI；the other types of HAI were blood stream infection(n=1), skin and soft tissue infection(n=1), antibioticassociated diarrhea(n=1),  and herpes zoster(n=1). Incidence of catheterassociated urinary tract infection (CAUTI), catheterrelated bloodstream infection (CRBSI),and ventilatorassociated pneumonia (VAP) per 1 000 catheter days were 2.94‰，2.12‰，and 15.72‰ respectively.ConclusionCAI is the main HAI type in ICU patients with  catheterization, and the major is VAP.