ObjectiveTo understand the serological detection of suspected measles cases in Xicheng District of Beijing, and provide basis for monitoring and prevention of measles.MethodsDetection results of 200 blood specimens and age distribution of suspected measles cases  in Xicheng District of Beijing in 2011-2014 were analyzed.   ResultsThe positive rate of serological detection of suspected measles cases in 20112014 was 32.50%（65/200）; positive rates in each year were 12.00%, 4.35%, 33.90%, and 44.09% respectively；there was significant difference in the positive rate of serological tests in different years（P＜0.001）.Of 200 cases, 65 were <5 years old, and 97 were >24 years old,  positive rates of serological detection were 35.38%  and 34.02% respectively; 31 cases (15.50%) received vaccination of measles; vaccine coverage rate in IgM antibody positive cases was lower than IgM antibody negative cases ( 3.08% vs 21.48%， P＜0.001）. ConclusionPositive rate of serological detection decreased in 2012, then increased year by year, for children under 5 years, measles are controlled by immunization with measles vaccine, in order to achieve the goal of eliminating measles effectively,  control and prevention of adult measles is of great significance.