ObjectiveTo explore effect of application of quality control circle (QCC) on improving the correct rate of hand hygiene (HH) among health care workers (HCWs)  in intensive care unit(ICU). MethodsQCC activity group was set up, the activity theme was established, correct rate of HH among HCWs in March 2014 (preintervention group) was monitored, the causes of incorrect HH behavior were analyzed, goals were set; from May 2014,  QCC activities were initiated, correct rate of HH between before performing QCC activities and September 2014 (postintervention group) was compared. Results834 and 900 times of HH among HCWs were investigated before and after performing QCC activities,  the number of correct HH before and after QCC activities were 360 and 714 respectively, correct rate of HH after implementing QCC was higher than before QCC activities （79.33% vs 43.17%， χ2=240.19， P＜0.05）.  The correct rate of HH  among HCWs of this ICU and HCWs engaging in advanced studies in this ICU after implementing QCC activities were both higher than before QCC activities（χ2=264.44, 6.36，respectively, both P＜0.05）. The main incorrect HH  before and  after  QCC was nonimplementation of HH indication. ConclusionApplication of QCC activities for the management of HH among HCWs can effectively improve the correct rate of HH among HCWs in ICU.