ObjectiveTo understand the psychological state, healthrelated quality of life (HRQOL) score, and the influencing factors of HRQOL score in patients with genital herpes. MethodsFrom January 2014 to August 2015, patients with genital herpes in dermatology outpatient clinic of Daping Hospital were investigated, and their psychological status was assessed by selfrating depression scale(SDS), HRQOL score was measured with the 36item short form health survey (SF36), correlation between HRQOL and SDS score,as well as influencing factors of HRQOL score were analyzed. ResultsA total of 145 patients with genital herpes were investigated, HRQOL and SDS scores were (479.46±92.45) and (62.2±14.1) respectively. Mild, moderate, and severe depression were 46 (31.73%)，28（19.31%），and 17（11.73%）cases respectively. Pearson correlation analysis showed that HRQOL score of the subjects was negatively correlated with SDS score (R=-0.37, P<0.001). Multiple linear stepwise regression analysis suggested that the factors related to HRQOL score from large to small were as follows: receive treatment, aware of genital herpes prevention knowledge, drinking, age, SDS score, sleep time, and exercise (all P＜0.05). HRQOL score was negatively related with age,drinking, and SDS score（all P＜0.05），but was positively related with treatment, exercise, aware of genital herpes prevention knowledge, and sleep time（all P＜0.05）. ConclusionMost patients with genital herpes suffer from depression, and with poor HRQOL, more attention must be paid to patients of old age and with depression, psychological intervention needs to be performed.