ObjectiveTo identify the occurrence and microorganism profile of deviceassociated healthcareassociated infections (DAHAIs) in the intensive care unit (ICU) of a university hospital in China.MethodsFrom January 1 to November 30, 2015, patients admitted to the ICU of a university hospital in China for more than 48 hours were performed prospective descriptive study. DAHAIs were defined according to the criteria of the Centers for Disease Control and Prevention (CDC) of U.S., descriptive statistical analysis was performed.ResultsOf 254 patients admitted to ICU, the overall incidence of DAHAIs was 15.35%, with 10.23 cases of DAHAIs per 1 000 ICUdays; the incidence of ventilatorassociated pneumonia (VAP), catheterassociated urinary tract infection (CAUTI), and central lineassociated bloodstream infection (CLABSI) were 7.05 per 1 000 ventilatordays, 4.91 per 1 000 urinary catheterdays, and 3.22 per 1 000 central linedays, respectively. The main infection site was lower respiratory tract, accounting for 48.27%, followed by bloodstream system(27.59%), urinary tract(22.99%), and gastrointestinal tract(1.15%). The major isolated microorganism was Acinetobacter baumannii (21.52%).ConclusionThe surveillance system can identify the epidemiological status of DAHAIs and make effective control measures to ensure the healthcare safety.