ObjectiveTo analyze factors affecting quality of life(QOL) in patients with chronic hepatitis B(CHB), and provide reference for improving QOL of patients. MethodsThe MOS 36item short form health survey (SF36) was adopted to survey QOL of patients with CHB, Morisky medication adherence scale was used to measure patients’ adherence to medication, factors affecting QOL of patients with CHB were analyzed. ResultsOf 357 CHB patients, 271(75.91%) were married, 107(29.97%) received college or above education, 163(45.66%) patients’ average household monthly income were ￥2 000-￥5 000, 138（38.66%）patients’ family members were also with CHB, 198 (55.46%) patients smoked, 150 (42.02%) drank. The average score of CHB patients’ adherence to medication was (2.15±1.29). Factors affecting QOL in patients with CHB were age, education level, duration of disease, whether or not hospitalized, whether or not drink, as well as adherence to medication. Age, drink, and duration of hepatitis B, and previous hospitalization were negative factors affecting QOL in patients with CHB, education level and adherence to medication were positive factors affecting QOL in patients with CHB. ConclusionStrengthening CHB patients’ understanding on disease and improving their medication adherence can help them to improve QOL.