ObjectiveTo investigate prognosis and related factors of infectious pancreatic necrosis(IPN) caused by multidrugresistant organisms(MDROs).MethodsClinical data of 53 IPN patients admitted to a hospital between October 2010 and March 2016 were analyzed retrospectively, patients were divided into MDRO infection group and common bacterial infection group according to antimicrobial resistance of pathogens isolated from peripancreatic drainge fluid, prognosis and related factors of two groups were compared.ResultsAmong 53 IPN patients with confirmed evidence for pathogenicity, 33（62.3%）were in MDRO infection group, and 20（37.7%）were in common bacterial infection group, the most common MDROs isolated from peripancreatic drainage was multidrugresistant Acinetobacter baumannii (MDROAB)（37.5%，18/48）. The mortality of IPN patients was 30.2% (16/53), mortality of MDRO infection group was higher than common bacterial infection group（39.4%［13/33］ vs15.0%［3/20］, P<0.05）; the severity score, length of intensive care unit (ICU) stay, and hospitalization expenses in MDRO infection group were all higher than common bacterial infection group(all P<0.05). The mortality of IPN patients were closely associated with MDRO infection and severity score of acute pancreatitis(all P<0.05).ConclusionPrognosis of patients with MDRO infection is poor, treatment is difficult, MDRO infection has become one of the most important challenge to the treatment of severe acute pancreatitis.