ObjectiveTo evaluate the effect of patients’ participating supervision on improving nurses’ compliance to hand hygiene(HH) in intensive care unit(ICU).MethodsImplementation of HH of ICU nurses was investigated by field observation and investigation of patients, intervention measures were began to be implemented in February 2016, HH compliance among ICU nurses after(FebruaryMay 2016) and before (November 2015January 2016) intervention was compared.ResultsA total of 81 patients were included in the study, 38 were in preintervention group and 43 were in postintervention group. 52.63%（20/38）in preintervention group and 88.37%（38/43）in postintervention group seen, heard or recalled that nurses had performed HH, difference was significant(χ2=12.67, P＜0.005)；after intervention, HH rates before and after touching a patient, before aseptic procedure, and after touching patient surroundings were all higher than before intervention (all P<0.01).ConclusionPatients’ participation in improving HH compliance of ICU nurses is feasible, and it is worth to be popularized.