ObjectiveTo carry out hand hygiene(HH) quality control circle(QCC) activity by using WeChat group, improve HH compliance of health care workers(HCWs), and enhance the circle members’ ability to solve problems.MethodsIn June 2015, 11 healthcareassociated infection control professionals in a hospital created HH WeChat group by using cellphones, activity cycle was once every two weeks, professionals analyzed the existing problems, and formulated countermeasures as well as implemented methods by group chat form, circle members introduced and implemented strategies to HCWs in their departments, so as to achieve the implementation effect.ResultsAfter the creating of WeChat QCC, HCWs’ HH compliance increased from 56.71% before activity to 85.94% after activity, difference was statistically significant (χ2=61.928, P<0.05); QCC members’ responsibility, selfconfidence, enthusiasm, harmony degree, team cohesiveness, quality control technique, communication, coordination, and problemsolving skill were all significantly improved.ConclusionApplication of WeChat QCC activity can improve HH compliance of HCWs and the ability of circle members.