ObjectiveTo observe the blocking efficacy of mother to child transmission (MTCT) in pregnant women with positive human immunodeficiency virus(HIV), and explore proper MTCT blocking mode for acquired immunodeficiency syndrome.MethodsClinical data of 23 HIVpositive pregnant women in a hospital from 2005 to 2015 were retrospectively analyzed.ResultsAll 23 HIVpositive pregnant women received highly active antiretroviral therapy (HAART) and comprehensive intervention for blocking MTCT of HIV. Among these women, 12 got pregnant after receiving HAART, 10 were detected positive HIV in early pregnancy (within 28 weeks) and then received HAART, 1 was detected positive HIV 28 weeks after pregnancy and then received HAART. 23 HIVpositive pregnant women all delivered normal newborns, followup observation of babies found no HIV infection.ConclusionHAART for HIVpositive pregnant women is the key to block MTCT of HIV, combined with preventive medication and artificial feeding of newborns, HAART can effectively prevent MTCT. Mutual blocking mode, such as HAART for HIVpositive pregnant women by specialists, pregnancy checkup, and preventive medicine for infants provided by maternity and child care hospital, is highly efficiency.