ObjectiveTo understand occurrence of handfootandmouth disease (HFMD) in Wuchuan Gelao Miao Autonomous County(hereinafter referred to as Wuchuan Autonomous County), and provide scientific basis for making measures of prevention and control of HFMD epidemic. MethodsDescriptive epidemiological method was used to analyze the occurrence of HFMD in Wuchuan Autonomous County in 2009-2014. ResultsIn 2009-2014, a total of 912 cases of HFMD in Wuchuan Autonomous County were reported, reported average incidence was 33.74/100 000, reported annual incidence were 5.83/100 000-87.88/100 000，incidence increased year by year, which peaked in 2014; Durn Town had the highest incidence (88.75/100 000), followed by Bocun Town(59.19/100 000) and Zhennan Town (46.30/100 000). Cases mainly concentrated in AprilJune, incidence in male was higher than female, HFMD mostly occurred in children under 3 years old, EV71 virus was the main pathogen, accounting for 45.05% of the total monitored cases. ConclusionIncidence of HFMD increased year by year in Wuchuan Autonomous County, cases mainly occurred in summer, scattered children are high risk population of HFMD.