ObjectiveTo establish emergency disposal procedures of healthcareassociated infection(HAI) in Pudong New Area, evaluate onsite investigation method, identify the key links and risk factors for infection, and timely control HAI outbreak. MethodsFrom January 2012 to December 2014, epidemiological investigation on HAI outbreaks in 65 hospitals in Pudong New Area was performed, emergency plan for disposal procedures of HAI was initiated, the emergency disposal procedures of each event was evaluated by experts. ResultsThere were 6 infection outbreaks occurred in Pudong New Area from January 2012 to December 2014, all were HAI, and no communityassociated infection existed simultaneously; 6 cases of HAI outbreaks involved 119 persons, the major were hospitalized patients (n=99,83.19%) and care workers (n=16,13.45%); 5 outbreaks all detected Norovirus, the main transmission route was close contact of nurses with patients during care for patients; the evaluation of each incident revealed that the total score was >90. ConclusionThe emergency disposal procedure of HAI suitable for Pudong New Area has been established, the effect is good and proved effective according to the expert evaluation on practical outbreaks.