ObjectiveTo investigate the clinical distribution and antimicrobial resistance characteristics of carbapenemresistant Acinetobacter baumannii (CRAB). MethodsCRAB isolated from all inpatients in a hospital in JanuaryDecember 2015 were performed retrospective analysis, antimicrobial susceptibility testing result was analyzed.ResultsA total of 721 AB strains were detected, 231 (32.04%) of which were CRAB, isolation rates of CRAB in quarter 1-4 were 48.99% (73/149), 41.98%（68/162）, 27.39%（63/230）, and 15.00%（27/180）respectively, which showed a decreased trend （P＜0.001）. CRAB mainly came from sputum specimen(n=140, 60.61%), followed by secretion of wound（n=33, 14.28%）and urine specimen(n=24，10.39%）. CRAB mainly distributed in intensive care unit, accounting for 43.72%(n=101), following by department of neurosurgery(n=37, 16.02%) , and burn/plastic surgery (n=22, 9.52%). Resistance rates of CRAB to ampicillin/sulbactam, gentamicin, levofloxacin, and ciprofloxacin were 85.28%-90.48%，resistance rate to tobramycin was low (19.48%），no strains were found to be resistant to polymyxin B. ConclusionAntimicrobial resistance of CRAB is serious, it is necessary to focus on management of key departments, take scientific prevention and control measures, so as to effectively reduce the incidence of healthcareassociated infection.