ObjectiveTo analyze the occurrence of sharp injuries among health care workers(HCWs), and put forward suggestions for safety management of sharp injuries.MethodsRecorded form of sharp injuries reported in a hospital in August 2006July 2015 were analyzed retrospectively, relevant data were analyzed statistically. ResultsA total of 211 sharp injuries occurred among HCWs were reported, sharp injuries mainly occurred among nurses(n=118, 55.92%) and doctors(n=83, 39.34%); 117(55.45%）sharp injuries occurred in HCWS whose length of service was ≤5 years; the main occurrence locations of sharp injuries were surgical ward（n=67， 31.75%）, internal medicine ward（n=65， 30.81%）, and outpatient as well as emergency departments（n=33，15.64%）；the main devices causing sharp injuries were syringe needle(n=91, 43.13%）, suture needle(n=34，16.11%), and scalp needle/transfusion needle（n=27，12.80%）；the main injuryrelated manipulations were all types of injection(n=40， 18.95%）, intravenous transfusion (n=38,18.00%）, and surgical suturing/cutting (n=36，17.06%）. The main opportunities of injuries was during manipulation(treatment, examination, operation, n=109, 51.66%）. Among bloodborne pathogens contaminated devices, contaminated by HBV, HCV, and HIV were 95（76.61%），25（20.16%），and 4 cases（3.23%） respectively. There was no bloodborne pathogen infection occurred. 155（73.46%）of 211 HCWs were inoculated hepatitis B vaccine. ConclusionPrevention of sharp injuries should be focused on nurses and doctors who work for ≤5 years, HCWs in surgical ward, internal medicine ward, and outpatient as well as emergency departments. Prevention of sharp injuries during manipulations such as injection, intravenous transfusion, suturing/cutting should be intensified. Related hospital departments should improve the reporting process and intensify followup.