ObjectiveTo analyze the epidemic characteristics of multidrugresistant tuberculosis (MDRTB) in Hunan Province from 2013 to 2016, and provide theoretical basis for the prevention and control of tuberculosis. MethodsInformation about TB patients in Hunan Province reported by China Information System for Disease Control and Prevention between January 2013 and December 2016 was analyzed retrospectively. ResultsFrom 2013 to 2016, the total drug resistance registration rate in Hunan Province was 5.53/million（1 496/270 330 000）, multidrug registration rate was 5.40/million（1 459/270 330 000）, drug resistance rate and multidrug resistance rate showed an upward  trends (trend χ2 =113.605, 96.590，respectively, both P<0.001）. Among MDRTB patients, male were more than females (74.09% vs 25.91%), most were more than 25 years of age, especially 45～ age group(27.07%); the proportion of patients with MDRTB retreatment was higher than that of the initial treatment (69.91% vs 30.09%). From 2013 to 2016, distribution range of MDR registration rates in different regions were 4.07/million - 7.23/million. ConclusionMDRTB in Hunan Province in 2013-2016 is increasing year by year, and mainly concentrate on young people over 20 years old. There are more cases of male and retreatment; it is necessary to strengthen regular treatment and prevention of key population, enhance the ability to identify and diagnose MDRTB patients, and reduce the spread of MDRTB.