ObjectiveTo evaluate the effect of targeted monitoring and comprehensive intervention measures on reducing the occurrence of catheterassociated urinary tract infection(CAUTI) in patients in nonintensive care unit(NonICU). MethodsIn quarter 4 of 2015, patients with indwelling urinary catheter in clinical departments were conducted a baseline survey(before intervention), risk factors for CAUTI in patients were analyzed, targeted monitoring programmes and comprehensive intervention measures were initiated in 2016(after intervention), incidence of CAUTI before and after intervention was compared. ResultsAfter taking intervention measures, hand hygiene compliance rate increased from 78.51% in quarter 4 of 2015 to 92.99% in quarter 3 of 2016 and 90.73% in quarter 4 of 2016（χ2=7.342, 3.998，respectively, both P＜0.05），the correct disposal rate of patients’ urinary catheterization system increased from 72.83% in quarter 4 of 2015 to 95.44% in quarter 4 of 2016（χ2=30.267，P＜0.05）. A total of 12 067 patients with indwelling urinary catheter were monitored, incidence of CAUTI dropped from 1.03‰（24/23 313）in quarter 4 of 2015 (before intervention) to 0.53‰（14/26 595）in quarter 4 of 2016(after intervention), difference was statistically significant（χ2=4.126，P=0.042）. ConclusionImproving the quality of urinary catheterization system in patients with indwelling catheter through targeted monitoring can effectively reduce the incidence of CAUTI in patients in NonICU.