ObjectiveTo evaluate the differences of serum RANTES(regulated on activation, normal T cell expressed and secreted), MCP1 (monocyte chemoattractant protein), and SDF1β (stromal cellderived factor1β) in patients with acquired immunodeficiency syndrome (AIDS) and healthy people. Methods38 AIDS patients who were admitted to a hospital between January 2010 and January 2015 were as AIDS groups, 38 healthy persons were as a healthy group, serum levels of RANTES, MCP1, and SDF1β in two groups were detected, and the subgroup analysis was carried out according to the viral load. ResultsSerum levels of RANTES, MCP1, and SDF1β in AIDS group were （1 392.55±227.69）pg/mL,（450.91±103.04）pg/mL, and（104.82±22.52）pg/mL respectively，all were significantly higher than those in healthy group（［120.58±55.87］ pg/mL, ［74.25±33.62］ pg/mL, and ［39.04±11.43］pg/mL respectively）(all P<0.05). Among AIDS patients with HIV viral load 4≤Log（VL）＜5 and Log（VL）≥5, serum RANTES were （1 470.34±155.01）pg/mL and （1 408.29±181.54）pg/mL respectively，which were both significantly higher than patients with HIV viral load Log（VL）＜4(［1 183.12±174.54］pg/mL)；serum MCP1 and SDF1β levels in AIDS patients with HIV viral load 4≤Log (VL)<5 were （537.93±89.32）and（149.31±18.05）pg/mL respectively，which were significantly higher than patients with HIV viral load Log（VL）≥5(［410.26±80.57］ pg/mL, ［81.53±20.31］pg/mL respectively) and HIV viral load Log（VL）＜4(［381.71±77.26］ pg/mL, ［72.90±21.62］pg/mL respectively)， differences were both statistically significant（both P<0.05）.ConclusionSerum levels of RANTES, MCP1, and SDF1β are significantly increased in AIDS patients, which are related to the level of viral load.