ObjectiveTo evaluate the effect of fulltime infection control nurses’ supervision on the compliance to implementation of comprehensive intervention measures and incidence of ventilatorassociated pneumonia(VAP). MethodsFulltime infection control nurses in the general intensive care unit(ICU) of a hospital were assigned, compliance to comprehensive intervention measures among all patients who were admitted to ICU was monitored. September 2012April 2014 was preintervention stage, May 2014December 2015 was postintervention stage. Utilization of ventilator and occurrence of VAP before and after implementing intervention measures were analyzed statistically.ResultsA total of 1 373 patients were monitored before intervention, 1 477 were monitored after intervention. Utilization rates of ventilator before and after intervention were 31.89% and 40.95% respectively. Incidence of VAP before and after intervention were 31.97‰ and 17.82‰ respectively, incidence of MDRO infection were 11.99‰ and 6.41‰ respectively. Microbial monitoring results of environmental object surface after intervention were all qualified (all≤5 CFU/cm2）. Fluorescence labeling clearance rate and hand hygiene compliance rate increased gradually in each quarter, reached more than 80% in the latter period; compliance to semireclining position was all 100% from the fourth quarter of 2014 to the fourth quarter of 2015.ConclusionThrough implementation of comprehensive intervention measures by fulltime infection control nurses, incidence of VAP can be decreased significantly, quality of medical treatment is improved, and safety of patients is ensured.