ObjectiveTo evaluate risk factors for central venous catheterrelated bloodstream infection(CRBSI) in intensive care unit(ICU) patients by Meta analysis. MethodsLiteratures about risk factors of CRBSI in ICU patients were retrieved from databases of Cochrane Library， PubMed， Embase， CBM， CNKI， and WanFang Data, RevMan 5.3 software was used for Meta analysis. ResultsThere are 12 literatures in accordance with the inclusion criteria, with a total sample size of 14 422 cases, 5 cohort studies and 7 casecontrol studies, the NewcastleOttawa Scale(NOS) scores were 4-6 points. According to Meta analysis, duration of indwelling catheter（WMD, 12.25 ［95%CI, 5.55-18.94］）, multicavity catheter（OR, 3.52 ［95%CI , 1.46-8.52］）, femoral vein catheterization（OR, 2.44 ［95%CI, 1.34-4.46］）, parenteral nutrition（OR, 2.47 ［95%CI, 1.18-5.21］）, length of stay in ICU（ WMD, 10.01 ［95%CI, 4.17-15.85］）, APACHE II score（WMD, 4.46 ［95%CI, 1.25-7.66］）, and diabetes mellitus（OR, 1.83 ［95%CI, 1.08-3.09］）were significantly different in each group (all P<0.05). ConclusionRisk factors for CRBSI in ICU patients are duration of indwelling catheter, multicavity catheter, femoral vein catheterization, parenteral nutrition, length of stay in ICU, APACHE II score, and diabetes mellitus. However, due to the limitation of methodological quality of included studies, more strictly designed and large sample prospective studies are needed to verify the result.