ObjectiveTo understand medical coping mode and its influencing factors among patients with tuberculosis(TB), and provide evidence for the development of clinical nursing strategies for TB patients.MethodsGeneral questionnaire and medical coping mode questionnaire(MCMQ) were used to investigate 402 TB patients in tuberculosis unit of a tertiary firstclass hospital in Changsha, medical coping mode and its influencing factors among TB patients were analyzed.ResultsThe scores of confrontation, avoidance, and acceptanceresignation dimensions of TB patients were (18.91±3.05), (15.49±2.62), and（10.00±3.01）respectively, score of confrontation dimension was statistically lower than domestic norm(P<0.05), but score of avoidance and acceptanceresignation dimensions were statistically higher than domestic norm(P<0.01). Factors influencing confrontation coping mode of TB patients were residence (city and town residents had a higher score, b=1.01, P=0.036), whether attending lecture on tuberculosis education (participants scored higher, b=1.71, P=0.001), and degree of understanding the disease conditions (the more understanding, the higher the score, b=0.55, P<0.001); factors that had significant influence on the avoidance dimension was the way of living (leading solitary life had a higher score, b=1.19, P=0.004); factors influencing acceptanceresignation of TB patients were course of tuberculosis(long duration scored higher, b=0.53, P=0.008), education degree (higher education level had lower score, b=-0.35, P=0.047), times of hospitalization due to tuberculosis (more hospitalization scored higher, b=0.58, P=0.002) and so on.ConclusionTB patients are prone to take avoidance and acceptanceresignation coping mode. The coping mode of TB patients is influenced by both demographic factors and disease factors such as residence， education level, the course of disease, times of hospitalization due to tuberculosis and so on.