ObjectiveTo analyze clinical features of children with measles in the department of infectious disease in a children’s hospital, provide basis for clinical diagnosis and treatment of measles. MethodsA retrospective analysis on demographic data, clinical features, laboratory examination, treatment, and prognosis of children with measles in a children’s hospital from January 1 to June 30, 2016 were analyzed retrospectively. ResultsA total of 248 children with measles were investigated, the average age was 18.2 months; 98 cases were aged ≤9 months, 150 were aged ＞9 months; 242 children with measles didn’t receive measles vaccination. Body temperature of 83.06% of children with measles was >39℃, the average course of fever was 7.8 days; 24 cases had atypical rash. Two groups of children were both mainly complicated with pneumonia, accounting for 93.95%; incidences of hoarseness, cough, laryngitis, and heart failure in children ≤9 months were higher than children>9 months (P<0.05); while typical rash, koplik spots, photophobia, respiratory failure, and severe measles were lower than children>9 months(P<0.05); there was no significant difference in the number of cured cases between two groups of children(P>0.05). Of 248 children with measles, 41 had peripheral white blood cells＞10×109/L；28.26% of children who complicated with pneumonia were isolated Streptococcus pneumoniae from sputum; 93.95% were reported pneumonia by chest Xray examination; 9 cases complicated with respiratory failure and used invasive mechanical ventilator, 6 cases cured, 3 died. ConclusionChildren aged>9 months who don’t receive measles vaccine are more, and they are prone to develop severe measles, and children aged ≤9 months are easily combined with heart failure.