ObjectiveTo understand the occurrence of totally implantable venous access port（TIVAP）related infection, and explore its risk factors.MethodsA total of 2 098 patients with breast cancer who received TIVAP in a tertiary firstclass hospital in Henan Province between January 2013 and December 2016 were selected as the research subjects. By nested case control study, 26 patients with TIVAPrelated infection during monitoring period were selected as case group, according to the proportion of 1∶2, 52 patients undergoing the same kind of operation during the same period were randomly selected as control group, difference in general data and research indexes between two groups was compared. Logistic regression model was used to analyze the risk factors for TIVAPrelated infection.ResultsDuring monitored period, the total TIVAP day was 274 838 days, 26 patients developed TIVAPrelated infection, incidence of TIVAPrelated infection was 1.24%, infection rate per 1 000 venous access day was 0.09‰; the main pathogen causing infection was Staphylococcus epidermidis (30.77%); independent risk factors for TIVAPrelated infection in patients were history of diabetes mellitus (OR, 3.61 ［95%CI, 1.27-10.11］), duration of venous access≥90 days (OR, 4.71 ［95%CI, 1.65-13.22］), and duration of operation≥40 minutes (OR, 3.60 ［95%CI, 1.34-9.64］). ConclusionIt is necessary to strengthen the monitoring and followup of patients receiving TIVAP, especially for patients with diabetes mellitus, as well as long duration of catheterization and operation, so as to prevent and control TIVAPrelated infection.