ObjectiveTo promote the meticulous management on whole process of healthcareassociated infection (HAI) through the development of new media function.MethodsIn 2016, with the help of WeChat enterprise number of the new media network tool, existing procedures were deeply integrated and optimized by means of information push as well as image and questionnaire survey, HAI prevention and control information platform was constructed, participation rate of the missing reporting and reporting of HAI during the process of implementation and operation of the platform in 2014-2016 were compared.ResultsIn 2016, the participation rate of reporting of HAI cases was 90.43%, with an increase of 26.34% compared with 64.09% in 2014, there was significant difference in reporting rate of HAI in three years（χ2=104.53， P＜0.001）. From 2014 to 2016, missing reporting rate of HAI were 14.63%, 10.81%, and 4.24% respectively, difference was statistically significant （χ2=53.85，P＜0.001）. From 2014 to 2016, the active reporting rate of HAI increased from 0 to 14.22%, the normal reporting rate of HAI increased from 12.88% to 44.17%, and the delayed reporting rate of HAI decreased from 87.12% to 41.61%.ConclusionThe innovative management mode of HAI based on new media is helpful for conducting prospective prevention and control of HAI, achieve the active management and realtime monitoring on HAI, and promote the closedloop management on the whole process of HAI prevention and control.