ObjectiveTo explore the prospective monitoring and control methods for missing reporting of healthcareassociated infection(HAI) cases, analyze its implementation efficacy,  provide basis for formulating targeted strategy for monitoring missing report of HAI.MethodsFrom January 2016 to June 2017, the quality control circle(QCC) method was used to prospectively monitor HAI cases in hospitalized patients, missing reporting of HAI was controlled.Results“Information system intelligence screening+mobile messaging alerts+ HAI supervision” trinity monitoring model for avoid missing reporting of HAI cases was established, after the first round of PDCA(plan, do, check, action) cycle, missing reporting rate of HAI decreased from 79.16% before QCC to 59.75% after QCC, difference was statistically significant (χ2=208.821, P=0.000). Compared with missing reporting rate of HAI after the first round of PDCA, missing reporting rate of HAI after the second round of PDCA dropped to 26.18%, difference was statistically significant (χ2=200.075, P=0.002).ConclusionActive prospective prevention and control before missing reporting of HAI can effectively avoid missing reporting of HAI cases.