ObjectiveTo evaluate the indirect economic burden of patients with severe healthcareassociated pneumonia (SHAP) in a tertiary firstclass specialty hospital through combined application of disabilityadjusted life year (DALY) and human capital method.MethodsAccording to DALY calculating method in the study of Global Burden of Disease (GBD), DALY of SHAP patients of each age group in a tertiary firstclass hospital from January 1, 2016 to December 31, 2017 was calculated, the indirect economic burden of SHAP patients was estimated by combining DALY with human capital method, patients were divided into two groups according to whether pathogens were multidrugresistant organisms (MDROs), indirect economic burden of two groups of patients was compared.ResultsAmong 71 SHAP patients, loss of DALY was 172.35 years, the average disease burden was 2.43 DALY, the average indirect economic burden was 51 428.37 Yuan. The average disease burden in SHAP patients in MDRO infection group (n=46 cases) and nonMDRO infection group (n=25 cases) were 3.36 and 0.71 DALY respectively, the average indirect economic burden were 77 235.32 and 3 957.18 Yuan respectively; difference in indirect economic burden between two groups of patients was statistically significant (P<0.05).ConclusionThe average disease burden and indirect economic burden of SHAP patients are not low, and indirect economic burden in SHAP patients with MDRO infection is higher than those with nonMDRO infection.