ObjectiveTo apply the receiver operating characteristic(ROC) curve to evaluate the predictive value of CD4+ T lymphocyte, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and platelet (PLT) in the prognosis of patients with acquired immunodeficiency syndrome(AIDS) and Talaromycosis marneffei (TSM）.MethodsA retrospective study was conducted on patients with AIDSassociated TSM in Liuzhou General Hospital from January 2013 to June 2015, patients were divided into improved group and deteriorated group according to prognosis, value of CD4+ T lymphocyte, ALT, AST and PLT in predicting the prognosis of patients were evaluated by ROC curve.ResultsA total of 96 cases of AIDS combined with TSM were initially treated, including 54 cases in improved group and 42 in deteriorated group. Serum ALT level in improved group was lower than that in deteriorated group (26.5［7.0, 148.0］ U/L VS 47.5［11.0, 116.0］ U/L). Serum AST level in improved group was lower than that in deteriorated group (49.0［10.0, 198.0］U/L VS 188.0［33.0, 435.0］ U/L). Plasma PLT level in improved group was higher than that in deteriorated group (133.0［13.0, 303.0］ ×109/L VS 33.5［7.0, 113.0］ ×109/L), CD4+ T lymphocyte level in improved group was higher than that in deteriorated group (24.0［5.0, 112.0］/μL VS 14.5［2.0,78.0］/μL), difference were all significant ( all P<0.05). ROC curve analysis showed that when AST≥2×ULN combined with PLT≤62×109/L, the area under curve (AUC) to predict the prognosis of TSM patients was 0.917 (95% CI: 0.835-0.998, P<0.05), sensitivity, specificity, positive predictive value, and negative predictive value were 90.0%, 93.3%, 93.1%, and 90.3%, respectively.ConclusionAST and PLT can be used as important prognostic indicators for prognosis of patients with AIDS and TSM, when AST≥2×ULN and PLT≤62×109/L, possibility of poor prognosis in TSM patients needs to be paid attention.