ObjectiveTo study clinical efficacy of ganciclovir in the therapy of infectious mononucleosis in adults. Methods66 adults with infectious mononucleosis in a hospital from January 2010 to December 2014 were studied retrospectively, according to drug therapy, patients were divided into ganciclovir therapy group (n=31) and symptomatic therapy group (n=35), clinical features before therapy, therapeutic efficacy, and EpsteinBarr virus(EBV) DNA negative conversion time were analyzed. ResultsThe time of defervescence, sore throat improvement, EBVDNA negative conversion, subside of enlarged lymph node, and transaminase recovery in ganciclovir therapy group were all shorter than symptomatic therapy group(all P<0.05). Blood routine recovery time between two groups was not significantly different(P>0.05). ConclusionGanciclovir has a good antiviral effect on the therapy of adult infectious mononucleosis, it can rapidly relieve patients from clinical symptoms including fever, sore throat and so on.
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