Objective To systematically evaluate the risk factors for death in patients with healthcare-associated infection(HAI) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB), and provide evidence for formulating prevention and control strategies. Methods Case-control studies on risk factors for death in patients with MDR-AB HAI were searched in computer database, patients died of MDR-AB HAI was in death group, those with MDR-AB HAI but survived was in survival group, Meta-analysis was carried out with RevMan 5.3 software after selecting literature, extracting data, and evaluating quality according to inclusion and exclusion criteria. Results A total of 1 204 patients with MDR-AB HAI in 11 studies were enrolled, 474 cases were in death group and 730 cases in survival group. Meta-analysis showed that old age (MD=3.99), hypoproteinemia (OR=2.1), mechanical ventilation (OR=4.23), tracheal intubation/tracheotomy (OR=2.5), deep venous catheterization (OR=2.21), post-transplantation (OR=3.12), and high APACHE Ⅱ score on admission (MD=2.33) were risk factors for death in MDR-AB patients (all P<0.05). Conclusion Risk factors for death in patients with MDR-AB HAI are complex, corresponding preventive measures should be taken.