Objective To explore the application effect of different scales of stroke-associated pneumonia (SAP) on predicting hospital-acquired pneumonia (HAP) in patients with ischemic stroke. Methods Data of patients with ischemic stroke admitted to department of neurology in a secondary general hospital from 2015 to 2018 were collected, the application of 6 SAP predictive scales in predicting HAP in patients with ischemic stroke was analyzed by recei-ver operating characteristic(ROC) curve, and performance of each predictive scale was evaluated. Results Data of 628 patients were collected, there were 44 cases of HAP (7.01%) and 46 cases of SAP (7.32%). C statistics of Kwon, Chumbler,A²DS²,PANTHERIS,ASI-APS,and ISAN were 0.731, 0.764, 0.729, 0.728, 0.66, and 0.778 respectively, except for ASI-APS sale, there were significant differences among the other 5 scales (all P<0.05), but there was no significant difference in the area under the curve of each score (all P>0.05). Comparison of predictive performance of HAP and reported SAP showed that Chumbler and ISAN had little difference in predicting HAP and SAP. Conclusion Except ASI-APS, other SAP predictive scales can be used to predict HAP in patients with ischemic stroke.