Central line-associated bloodstream infection (CLABSI) is one of the common complications of continuous renal replacement therapy(CRRT), it not only increases the usage rate of antimicrobial agents, prolongs patient's length of hospital stay, but also increases the cost of hospitalization. This paper summarized the relevant literatures in recent years on occurrence status, risk factors, as well as prevention and control measures of CLABSI in CRRT patients, aims to arouse great attention of clinical health care workers, and provide basis and reference for the prevention and control of CLABSI in CRRT patients.