Objective To investigate the incidence of hemodialysis events in an outpatient department on the basis of application of monitoring software. Methods According to National Healthcare Safety Network (NHSN) hemodialysis event monitoring manual, and relying on the outpatient hemodialysis event monitoring software, the occurrence of hemodialysis events in patients undergoing hemodialysis maintenance in hemodialysis center in a hospital at the first two working days in each month from January to December 2017 were monitored. Results From January to December 2017, a total of 4 006 hemodialysis patients were monitored, 138 dialysis events occurred, incidence of hemodialysis events was 3.44%, 130 of which were treated with antimicrobial agents (52 intravenously, 78 orally), 4 cases were positive for blood culture, and 4 cases were infected at blood vessel puncture site. Accor-ding to different types of vascular access, the highest incidence of hemodialysis events was non-tunnel central catheter (7.33%). Among 130 patients who received antimicrobial agents, a total of 179 cases of infection occurred, mainly upper respiratory tract infection (94 cases). Incidence of hemodialysis events increased firstly and then decreased in each month of 2017, with the highest rate (19.02%) in April. Conclusion Outpatient hemodialysis events are mainly caused by systemic use of antimicrobial agents, incidence of hemodialysis events in non-tunnel central venous catheter patients is high, information monitoring can be used as a mean of monitoring outpatient hemodialysis events.