Fosfomycin is an early discovered natural antibiotic with unique antimicrobial mechanism, by blocking the first step in the synthesis of bacterial cell wall, it can act on gram-positive bacteria and gram-negative bacteria, and is a rapid bactericide in reproductive period of bacteria and can destroy or inhibit formation of bacterial biofilm. In recent years, under the current severe drug resistance situation, fosfomycin has become a widely studied and applied antibiotic because of its unique antimicrobial mechanism, pharmacokinetic characteristics and low cross-resis-tance, especially for multidrug-resistant organisms, as an important combined used antibiotic, fosfomycin has been applied more and more widely in clinical practice.