Objective To explore infection control and implementation scheme under ventilator sharing management mode. Methods Demand of ventilator use and management in a hospital was investigated, infection prevention and control module as well as healthcare-associated infection survey module and so on for ventilator sharing were designed, information management of end sterilization of shared ventilators was achieved by intelligent APP on mobile phone and computer, actual operation test and efficacy detection of infection control module for 12 shared ventilators was conducted since November 2018. Results From November 14, 2018 to January 8, 2019, 7 ventilators were shared by 5 departments, the borrowing time was 24-1 288 hours, the total borrowing time was about 1 698 hours, the average borrowing time was 242.57 hours per time. The average daily use time of 12 shared ventilators was 2.62 hours/day. All 12 ventilators were idle in the department before sharing, and the average daily use time was 0 hour/day. Under the visual automatic prompt of infection prevention and control module, 12 shared ventilators were all qualified for disinfection after use, and all the self-testings were passed. Conclusion Ventilator sharing can save cost, meet clinical needs and improve infection management efficiency.