After the introduction of revision of "Specification of hand hygiene of health care workers WS/T 313-2019", the requirements of hand disinfection for health care workers are more standardized. Hand disinfectant is an effective tool to improve hand hygiene and reduce hand-borne pathogenic microorganisms, national compulsory standard of "Hygienic requirements for hand antiseptic agents GB 27950-2010" stipulates the hygienic requirements for hand disinfectant, but there is no specific requirement for the inactivated virus markers. At present, the commonly used hand disinfectant in the market is mainly alcohol or alcohol-based hand disinfection product, but effect of alcohol disinfectant on inactivation of enteroviruses with strong disinfection resistance is disputed. In this paper, the domestic and foreign studies on the effect of hand disinfectant on inactivation of enterovirus are reviewed, so as to provide reference for health care workers to select hand disinfectant rationally.