Objective To understand epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19), and reveal the risk factors related to treatment outcome. Methods Clinical data of patients with COVID-19 admitted to a tertiary hospital in Wuhan from December 27, 2019 to January 30, 2020 were retrospectively analyzed, treatment outcome was followed up, according to the treatment outcome, patients were divided into survival group(improved and discharged)and death group, risk factors related to treatment outcome were identified through univariate and multivariate analysis. Results During the follow-up to March 3, 2020, among 100 patients with COVID-19 after treatment, 85 cases were improved and discharged (survival group), 15 cases died (death group). The median age of patients was 44.0 years old, female patients accounting for 60.0%, 1 patient with positive SARS-CoV-2 nucleic acid test showed no other clinical manifestation except chest CT finding of "right lung patch opacity". Univariate analysis showed that percentage of patients in death group were all higher than survival group in the following factors:age ≥ 60 years old, had a history of chronic heart disease, chronic lung disease, cerebrovascular disease, diabetes mellitus, hypertension, severe or critical clinical types at admission, laboratory tests of platelet count<100×10⁹/L, lymphocytic cell count<0.5×10⁹/L, lactate dehydrogenase ≥ 250 U/L, alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) ≥ 40 U/L, serum creatinine ≥ 97 μmol/L, fibrinogen ≥ 4 g/L, D-dimer ≥ 1 mg/L, without treatment of traditional Chinese medicine and mechanical ventilation (all P<0.05). Multivariate analysis showed that severe or critical clinical type and chronic heart disease are independent risk factors for death (P<0.01). Conclusion Treatment outcome of COVID-19 is related to multiple factors, severe or critical clinical types at admission and combines with chronic heart disease are independent risk factors for death.