Effective antiviral therapy and vaccine preventive measure for coronavirus disease 2019(COVID-19) is still not ascertained at present. Combined with the previous evidence and therapeutic plan formulated based on clinical first-line therapeutic experience of COVID-19, research progress in drug therapy for COVID-19 was reviewed from the aspect of antiviral drugs such as nucleoside reverse transcriptase inhibitors and nucleoside analogues, as well as convalescent plasma therapy.