In order to fight against the epidemic of coronavirus disease 2019(COVID-19), medical teams from all over the country went to Wuhan for aiding medical rescue, infection control professionals(ICPs) have become an indispensable power of medical teams. Doing a good job in infection control can effectively reduce the risk of infection of medical team members. Based on the practice, this paper summarizes the experience of carrying out the work of infection control by ICPs in medical teams for aiding Hubei Province, including the establishment of infection control team, conducting infection control training, formulating control measures in the residents, monitoring and disposing infection and exposure, optimizing layout of three region and process of putting on and taking off personal protective equipment(PPE), supervising putting on and taking off PPE, guiding cleaning and disinfection, establishing each infection control system in epidemic period, supervising clinical infection control and so on.